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Mutations in genes underlying atypical familial mycobacteriosis are not found in tuberculosis patients from Siberian populationsВ журнале Tuberculosis вышла статья Алексея Рудко с соавторами: Alexey A. Rudko, Anna F. Garaeva, Elena Yu. Bragina, Nadezda P. Babushkina, Olga V. Kolokolova, Olga N. Lipaenkova, Valery P. Puzyrev, Maxim B. Freidin Mutations in genes underlying atypical familial mycobacteriosis are not found in tuberculosis patients from Siberian populations. Tuberculosis. 2015. р. 1-4 S u m m a r y Objectives: Atypical familial mycobacteriosis (AFM, OMIM #209950) is caused by mutations in genes regulating IL12/IFNG pathway. Some of the mutations exhibit incomplete penetrance, and they have been proposed to be involved in the common (polygenic) predisposition to tuberculosis (TB). We set out to test this hypothesis in two populations from Siberian region of Russia with high prevalence of TB.
просмотров: 3134, опубликовано: 17.02.2015
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