Induced pluripotent stem cell line, IMGTi003-A, derived from skin fibroblasts of an intellectually disabled patient with ring chromosome 13
В ноябрьском номере журнала "Stem Cell Research" опубликована статья сотрудников лаборатории цитогенетики НИИ медицинской генетики Томского НИМЦ в соавторстве с томскими и новосибирскими коллегами "Induced pluripotent stem cell line, IMGTi003-A, derived from skin fibroblasts of an intellectually disabled patient with ring chromosome 13".
T.V. Nikitina, A.G. Menzorov, A.A. Kashevarova, M.M. Gridina, A.A. Khabarova, S. Yakovleva Yu, M.E. Lopatkina, I.E. Pristyazhnyuk, S.A. Vasilyev, O.L. Serov, I.N. Lebedev. Induced pluripotent stem cell line, IMGTi003-A, derived from skin fibroblasts of an intellectually disabled patient with ring chromosome 13 // Stem Cell Research.
Abstract
Skin fibroblasts from a patient with neurodevelopmental and speech delay, anxiety disorder, macrocephaly, microorchidism, multiple anomalies of internal organs and ring chromosome 13 were reprogrammed into induced pluripotent stem cells (iPSCs) to generate a clonal stem cell line IMGTi003-A (iTAF6-6). IMGTi003-A pluripotency was demonstrated by three germ layer differentiation capacity in vitro, and this cell line had a mosaic karyotype with 46,XY,r(13) as a predominant cell subpopulation. IMGTi003-A line is a good model for studying of the mitotic instability of the ring chromosome 13.
Статья доступна в электронном варианте по ссылке:
https://www.sciencedirect.com/science/article/pii/S1873506118302782#gts0005
https://doi.org/10.1016/j.scr.2018.11.009
просмотров: 2433, опубликовано: 27.11.2018
